inForm
inForm is a versatile formulation workstation that fills the gap between research-based micro-scale dissolution and the compendial world. It allows for precise pH control and monitoring, enabling you to study dissolution under conditions that mimic in vivo conditions more closely that other systems.
inForm can be used to provide biorelevant dissolution and solubility data to help you make formulation decisions more effectively.
Overview
inForm enables innovative methods such as biphasic dissolution, gradient pH adjustment and controlled supersaturation to show how a drug would behave under biorelevant conditions. It can accommodate multiple dosage forms and sample types with quantitation by in-situ UV-dip probes. There is also the built-in option to automatically remove aliquots for off-line quantitative analysis. Notably, inForm also includes the industry standard UV-metric and pH-metric methods for the determination of pKa and solubility for ionizable substances featured on the Sirius T3. This enables extensive physchem characterization for your API and its formulations.
Applications
inForm is a highly versatile platform, designed to offer a suite of automated dissolution and supersat-uration testing tools, which together provide:
✓ Biorelevant and traditional multi step dissolution assays with pH control
✓ Built-in assays, including dissolution, biphasic dissolution and pH-metric dissolution
✓ Ability to study API or formulated samples
✓ Physchem characterization for drug compounds
✓ Evaluation of the effects of excipients and other formulation additives on sample solubility and the duration and extent of supersaturated states
Features
Relevance
inForm provides high-quality support for formulation development, reflecting industry’s growing interest in dissolution to support in vivo prediction.
Part of the Pion Dissolution Family
Pion products are engineered to work together to simplify dissolution challenges.
Part of the Pion suite of PhysChem Analysis Tools
Pion products are engineered to work together to support PhysChem Analysis.
Versatility
inForm assays are capable of handling samples as powders, granules or whole dosage forms; liquids can be solutions, suspensions and low viscosity lipid-based formulations.
inForm assays allow the user to control instrument functions such as data collection rate, assay dura-tion, automatic pH control, methods of sample introduction and more.
Precision
inForm’s precision engineered hardware ensures fluid and sample additions are tightly controlled by high accuracy fluid dispensers. Assay stirring speeds are kept consistent and temperature is constant-ly managed. This means that experiments performed on inForm are highly reproducible.
The built-in spectrophotometer allows for the UV quantitation of samples across multiple wave-lengths simultaneously, while also enabling the deconvolution and quantitation of multi-component samples. Variable path length tips are also available to suit compounds with sparing or extreme UV absorbance.
inForm’s software fully tracks and records temperature, spectra, pH, and reagent volumes for every data point of every assay, providing a wealth of information for all instrument applications.
Robotics
inForm has a fully automated X, Y and Z axis on both arms, allowing you to run complicated assays that would be challenging to set up manually. The probe arm is equipped to facilitate complete automa-tion, enabling instrument-controlled reagent addition, temperature control, spectra collection, pH measurement, and sample addition. The vial arm allows sequences of up to 20 assays to be queued and is also equipped with a sampling needle capable of introducing liquid samples or collecting ali-quots from running assays for offline analysis.