miniDISS Profiler
The miniDISS Profiler™ is a Rainbow in situ Fiber Optic UV monitoring system with the miniDT dissolution tester and is designed for biorelevant media volumes. It is ideal for measuring high-potency API or when low concentrations are expected, typical of Pre-Formulation and Formulation activities.
Designed to work with the Pion Rainbow Dynamic Dissolution Monitor, the miniDT Dissolution Tester may be used independently.
Overview
The miniDISS Profiler™ is Pion’s industry recognized Rainbow Fiber Optic UV-vis platform technology with a small volume dissolution tester for testing biorelevant volumes using vessels of 100-250 ml. It is ideal for measuring high-potency API or when low concentrations are expected and can be used to evaluate solubility, dissolution profiles, supersaturation, precipitation profile and more, with simultaneous real-time data collection and analysis and a powerful yet user-friendly graphic display.
Designed to work with the Pion Rainbow Dynamic Dissolution Monitor, the miniDT Dissolution Tester may be used independently.
Applications
✓ Formulation development
✓ Oral dosage form dissolution for sink and non-sink conditions
✓ High potency drug products testing
✓ Pediatric drug products development
✓ Biorelevant volumes
Features
Flexibility in small volume testing
• Eliminates time-consuming swap out and revalidation requirements when switching from large to small volumes
• Eight-position stirring system with interchangeable 100 ml, 150 ml or 200 ml standard vessels or 250 ml Chinese Pharmacopiea vessels
Industry standard Rainbow technology
• Data collection of the full UV Spectra (200 - 720 nm) as fast as every two seconds
• Dip-Style Fiber Optic Probes with interchangeable path length tips
microDISS
The MicroDISS Profiler™ is an innovative insitu fiber optic UV monitoring system, specifically designed to monitor concentration in real-time from small volume dissolution assays. It is powered by AuPRO™; the most comprehensive dissolution data analysis software in the industry.
Overview
The microDISS Profiler™ is Pion’s industry recognized platform technology, which can be used to evaluate solubility, intrinsic disc dissolution rate, dissolution profiles, supersaturation, precipitation profile… and more, with simultaneous real-time data collection and analysis and a powerful yer user-friendly graphic display.
Applications
The microDISS Profiler™ can be used to bring greater accuracy to many pre-clinical dissolution studies, including:
✓ Small volume dissolution – tablets and powder
✓ Nanoparticle dissolution
✓ Intrinsic dissolution
✓ Biorelevant dissolution
✓ Excipient and salt screening
✓ Dynamic pH change
✓ Polymorphic change
✓ Solubility – Aqueous and Non-Aqueous
✓ Follow stability profiles
✓ Nanoparticle solubility
✓ Supersaturation studies
✓ Determine equilibrium solubility
✓ Micronisation effect on dissolution
Features
Versatile
Smart software and flexible architecture allow for multiple experimental conditions on a single platform.
Robust
The MicroDISS Profiler™ employs dip-style probes engineered in stainless steel.
Fast and Accurate
Up to 8 individual Photo Diode Array Spectrophotometers allows data collection of UV/VIS spectra (200 – 720 nm) at 1nm resolution as often as every two seconds from all vessels simultaneously.
Cost-effective
Ideal for small volume dissolution (2-20 mL), with interchangeable pathlength tips to bring the cost-efficiencies of combined speed and flexibility.